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II. Natural Derivative
Synthetic substance, no natural derivative
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III. Chemical Profile ( IUPAC name)
(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate
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IV. History
Simvastatin was developed in the 1980s and became available in the 1990s. It is widely used for lowering cholesterol and reducing the risk of cardiovascular disease.
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V. Legal Information
Simvastatin is available by prescription and is considered safe when used as directed. It is regulated to ensure proper labeling and dosage instructions.
Key US Federal Policies:
Simvastatin is regulated by the FDA, with specific guidelines for prescription use to ensure safety and efficacy.
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VI. Physical Effects
Simvastatin is a statin that works by inhibiting HMG-CoA reductase, reducing cholesterol synthesis. This lowers blood levels of low-density lipoprotein (LDL) cholesterol and triglycerides, while increasing high-density lipoprotein (HDL) cholesterol.
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VII. Psychological Effects
Simvastatin does not have significant psychoactive effects. Its primary action is to lower cholesterol levels, reducing the risk of heart disease and stroke.
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VIII. Culture
Simvastatin is widely used for its effectiveness in managing high cholesterol and preventing cardiovascular events. It is included on the WHO Model List of Essential Medicines and is a standard treatment for hypercholesterolemia.
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