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Name: (Positional Isomer: 2,5-Dimethoxy-4-ethylthioamphetamine (Aleph-2)) 2-(ethylamino)-2-(3-methoxyphenyl)cyclohexan-1-one (methoxetamine)
Type:
AKA: MXE, methoxetamine
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II. Natural Derivative
Synthetic substance, no natural derivative
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III. Chemical Profile (IUPAC name)
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IV. History
This was a discovery of a chemical compound which was first synthesized in the 1930s by Dr. Charles G. Kober and his colleagues. The compound was called 2-(ethylamino)-2-methoxy-5-methylcyclohexanone (aleph 2) and was synthesized from ethylamine and cyclohexanone. The compound was tested in animals and was found to have a hypnotic effect.
In 1943, Kober and his colleagues synthesized a derivative of aleph 2 which was called 2-(3 methoxyphenyl)cyclohexan-1-one (methoxetamine). Methoxetamine was shown to be a very powerful and selective drug in the treatment of anxiety disorders. It was used in the treatment of anxiety disorders for more than 60 years.
In 1962, Kober and his colleagues synthesized a derivative of methoxetamine which was called 2-(methox
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V. Legal Information
Methoxetamine, a dissociative anesthetic, is classified as a Schedule I controlled substance in the US, making it illegal. Many countries have similarly banned it due to its potent psychoactive effects. The UNODC monitors new psychoactive substances, emphasizing the need for international regulation to prevent misuse. Trends show increasing global control measures.
US Federal Schedule - I
Schedule I drugs, substances, or chemicals are defined as drugs with no currently accepted medical use and a high potential for abuse. Some examples of Schedule I drugs are: heroin, lysergic acid diethylamide (LSD), marijuana (cannabis), 3,4-methylenedioxymethamphetamine (ecstasy), methaqualone, and peyote.
Key US Federal Policies:
Controlled Substances Act. Public Law: Public Law 91-513 (text can be found on GovInfo) (https://www.dea.gov/drug-information/csa). Date enacted: October 27, 1970.
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VI. Physical Effects
Methoxetamine is a dissociative anesthetic with stimulant properties. It acts as an upper and dissociative, causing euphoria and altered perception. Short-term use can produce intense effects, while long-term impacts include psychological issues and potential dependency. Overdose risks involve severe dissociation and cardiovascular effects. Safe use involves cautious dosing. Recent studies investigate its psychoactive properties and health risks.  |
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VII. Psychological Effects
Methoxetamine, a synthetic dissociative, affects NMDA receptors, providing dissociative and euphoric effects. Immediate effects include altered perception and mood, while long-term use may lead to cognitive impairments and psychological issues. Research examines its safety and psychological impact.
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VIII. Culture
Methoxetamine (MXE) is a dissociative anesthetic similar to ketamine, producing hallucinogenic and sedative effects, classifying it as a downer. Short-term use can cause euphoria, dissociation, and altered perception, while long-term use may lead to bladder toxicity and cognitive impairment. Overdose can result in severe agitation, hallucinations, and fatal respiratory depression. Safe usage is not well-established, but lower dosages are recommended. Recent research warns of significant abuse potential and health risks. Physical signs include altered mental state, nausea, and impaired motor function.
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