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Name: (Positional Isomers: 2,4,5-Trimethoxy-amphetamine (TMA-5), 2,4,6-Trimethoxy-amphetamine (TMA-6), Escaline) 3,4-Methylenedioxyamphetamine
Type:
AKA: MDA, Love Drug
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II. Natural Derivative
Synthetic substance, no natural derivative
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III. Chemical Profile (IUPAC name)
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IV. History
The isomers of trimethoxy-amphetamine and 3,4-methylenedioxyamphetamine (MDMA) were developed in the mid-20th century as part of research into psychoactive substances. TMA compounds and MDMA have been studied for their effects on mood and perception, with MDMA becoming particularly well-known for its use in psychotherapy and recreational settings. The research on these compounds has contributed to the understanding of psychoactive drugs.
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V. Legal Information
The positional isomers 2,4,5-Trimethoxyamphetamine (TMA-5), 2,4,6-Trimethoxyamphetamine (TMA-6), and Escaline, along with 3,4-Methylenedioxyamphetamine (MDMA), are often regulated under analog laws. In the US, these substances could be controlled under the Federal Analog Act if deemed similar to other controlled substances. Globally, they face similar restrictions as part of broader efforts to manage psychoactive substances.
US Federal Schedule - I
Schedule I drugs, substances, or chemicals are defined as drugs with no currently accepted medical use and a high potential for abuse. Some examples of Schedule I drugs are: heroin, lysergic acid diethylamide (LSD), marijuana (cannabis), 3,4-methylenedioxymethamphetamine (ecstasy), methaqualone, and peyote.
Key US Federal Policies:
Controlled Substances Act. Public Law: Public Law 91-513 (text can be found on GovInfo) (https://www.dea.gov/drug-information/csa). Date enacted: October 27, 1970.
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VI. Physical Effects
This category includes various positional isomers like TMA-5, TMA-6, and Escaline, which are psychedelics. As uppers, they induce significant changes in perception and mood. Short-term effects include vivid hallucinations and altered sensory experiences, while long-term use can lead to psychological issues. Overdose risks involve severe agitation and psychosis. Safe dosing varies widely, and recent findings focus on their powerful hallucinogenic effects and potential for psychological impact.  |
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VII. Psychological Effects
This compound, combining various psychedelics, affects serotonin receptors, leading to altered perception and mood. Immediate effects include hallucinations and euphoria, while long-term use may cause cognitive impairments and psychological issues. Research focuses on the individual and combined effects of these substances on mental health and cognition.
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VIII. Culture
This group of compounds, including TMA-5, TMA-6, and escaline, are psychedelics with hallucinogenic effects. Their cultural significance is tied to the exploration of psychedelic substances and their potential therapeutic uses. These compounds represent the broader interest in psychedelics and their effects on consciousness. Their role in the cultural narrative is one of exploration and expanding the understanding of psychedelic experiences, reflecting ongoing curiosity about these substances.
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