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Name: (Positional Isomer: 2,5-Dimethoxy-4-ethylthioamphetamine (Aleph-2)) 2,5-Dimethoxy-4-ethylamphetamine
Type:
AKA: DOET
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II. Natural Derivative
Synthetic substance, no natural derivative
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III. Chemical Profile (IUPAC name)
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IV. History
2,5-Dimethoxy-4-ethylamphetamine (DOET) is a psychedelic compound first synthesized by Alexander Shulgin. It is a positional isomer of 2C-E, with similar effects. DOET has been used in research to understand the structure-activity relationships of psychedelic compounds. Its use is largely limited to scientific studies and the exploration of human consciousness.
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V. Legal Information
2,5-Dimethoxy-4-ethylthioamphetamine (Aleph-2) is a psychedelic compound that is controlled in many jurisdictions due to its hallucinogenic effects. In the US, it is classified as a Schedule I substance, making its production, distribution, and use illegal. Internationally, Aleph-2 is similarly regulated under various national drug laws. The trend is towards maintaining strict controls to address the risks associated with such substances.
US Federal Schedule - I
Schedule I drugs, substances, or chemicals are defined as drugs with no currently accepted medical use and a high potential for abuse. Some examples of Schedule I drugs are: heroin, lysergic acid diethylamide (LSD), marijuana (cannabis), 3,4-methylenedioxymethamphetamine (ecstasy), methaqualone, and peyote.
Key US Federal Policies:
Controlled Substances Act. Public Law: Public Law 91-513 (text can be found on GovInfo) (https://www.dea.gov/drug-information/csa). Date enacted: October 27, 1970.
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VI. Physical Effects
2,5-Dimethoxy-4-ethylamphetamine (Aleph-2) is a synthetic psychedelic known for its hallucinogenic effects. As an upper, it induces intense visual and auditory hallucinations. Short-term effects include altered sensory perception, increased heart rate, and dilated pupils, while long-term use may result in persistent psychological effects. Overdose risks include severe agitation and psychosis. Safe use involves cautious dosing, but recent research highlights its high potential for misuse and the need for regulation due to possible adverse effects.  |
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VII. Psychological Effects
2,5-Dimethoxy-4-ethylthioamphetamine (Aleph-2) affects serotonin receptors, leading to altered perception and mood. Psychological effects include hallucinations and euphoria, lasting 6-8 hours. Long-term use may lead to persistent changes in perception. Recent research investigates its potential therapeutic uses and psychological risks.
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VIII. Culture
2,5-Dimethoxy-4-ethylamphetamine (DOET), a psychedelic compound, has been part of the broader psychedelic culture since the mid-20th century. It is chemically related to other phenethylamines, such as mescaline and 2C-B. DOET’s cultural significance lies in its use in experimental and recreational contexts, often associated with the counterculture movements of the 1960s and 1970s. The substance represents the exploration of altered states of consciousness and the quest for spiritual and personal insights. While not as well-known as other psychedelics, DOET is part of the narrative of psychedelic research and the ongoing interest in the therapeutic potential of these substances.
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