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Name: 1-[1-[1-(4-bromophenyl)ethyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one) Bufotenine
Type: Psychedelic tryptamine
AKA: Mappine, N, N-dimethylserotonin
![1-[1-[1-(4-bromophenyl)ethyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one) Bufotenine image](https://grammasearch.com/dev/v2/aiimages/1-%5B1-%5B1-%284-bromophenyl%29ethyl%5D-4-piperidinyl%5D-1%2C3-dihydro-2h-benzimidazol-2-one%29_bufotenine.png)
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II. Natural Derivative
Synthetic substance, no natural derivative
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III. Chemical Profile (IUPAC name)
![1-[1-[1-(4-bromophenyl)ethyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one (Bufotenine) image](/dev/v2/pages/pubchem_images/10823.png)
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IV. History
Bufotenine, first isolated from toad venom in 1934 by the German chemist Albert Hofmann, is a naturally occurring tryptamine with hallucinogenic properties. Its synthetic analogs, including the one with the 4-bromophenyl group, were developed in the mid-20th century. Bufotenine has been studied for its psychoactive effects and potential medicinal uses, although it remains relatively obscure in the field of psychopharmacology.
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V. Legal Information
1-[1-[1-(4-bromophenyl)ethyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one and bufotenine are synthetic compounds that may be regulated under analog laws due to their psychoactive properties. In the US, such substances could fall under the Federal Analog Act. Globally, their status is increasingly restrictive, reflecting efforts to control novel psychoactive substances.
US Federal Schedule - I
Schedule I drugs, substances, or chemicals are defined as drugs with no currently accepted medical use and a high potential for abuse. Some examples of Schedule I drugs are: heroin, lysergic acid diethylamide (LSD), marijuana (cannabis), 3,4-methylenedioxymethamphetamine (ecstasy), methaqualone, and peyote.
Key US Federal Policies:
Controlled Substances Act. Public Law: Public Law 91-513 (text can be found on GovInfo) (https://www.dea.gov/drug-information/csa). Date enacted: October 27, 1970.
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VI. Physical Effects
Bufotenine is a naturally occurring tryptamine with psychedelic properties. It acts as an upper, causing hallucinations and altered perceptions. Short-term use can lead to intense psychological effects, but long-term effects are not well understood. Overdose risks include severe psychological distress and potential toxicity. Safe use involves cautious dosing. Recent research investigates its pharmacological effects and potential therapeutic uses.  |
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VII. Psychological Effects
Bufotenine, a psychedelic, affects serotonin receptors, causing altered perception and mood. Immediate effects include hallucinations and euphoria, with potential long-term cognitive impacts. Research highlights its psychoactive effects, therapeutic potential, and risks associated with its use.
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VIII. Culture
Bufotenine, a naturally occurring psychedelic, has cultural significance related to its traditional use in indigenous rituals and its exploration in modern research. Known for its hallucinogenic properties, bufotenine is associated with shamanic practices in South America. Its role in the cultural narrative includes both historical use in spiritual contexts and contemporary research into its potential therapeutic benefits, highlighting the intersection of traditional and modern approaches to psychedelics.
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