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Name: 2-(4-iodo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl) ethanamine (25I-NBOMe)
Type: Psychedelic phenethylamine
AKA: 25I-NBOMe, 2C-I-NBOMe, 25I, Cimbi-5
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II. Natural Derivative
Synthetic substance, no natural derivative
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III. Chemical Profile (IUPAC name)
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IV. History
25I-NBOMe, a synthetic hallucinogen, was developed in the early 2000s as part of a series of NBOMe compounds. It gained notoriety for its potent psychoactive effects and has been associated with significant health risks, leading to its inclusion in various regulatory lists.
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V. Legal Information
2-(4-Iodo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine (25I-NBOMe) is a synthetic psychedelic with high abuse potential. It is classified under Schedule I in the United States and similarly regulated in other countries to control its misuse. [Source: UNODC].
US Federal Schedule - I
Schedule I drugs, substances, or chemicals are defined as drugs with no currently accepted medical use and a high potential for abuse. Some examples of Schedule I drugs are: heroin, lysergic acid diethylamide (LSD), marijuana (cannabis), 3,4-methylenedioxymethamphetamine (ecstasy), methaqualone, and peyote.
Key US Federal Policies:
Controlled Substances Act. Public Law: Public Law 91-513 (text can be found on GovInfo) (https://www.dea.gov/drug-information/csa). Date enacted: October 27, 1970.
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VI. Physical Effects
25I-NBOMe is a potent psychedelic phenethylamine first synthesized in the 2000s. It acts as an upper, inducing strong visual and auditory hallucinations. Physical impacts include dilated pupils, increased heart rate, and elevated blood pressure. Short-term use can lead to intense sensory distortions and anxiety, while long-term use may result in persistent psychosis or cognitive issues. Overdose risks include severe agitation, cardiovascular distress, and potential fatalities. Safe use is challenging due to its potency; recent research highlights its safety concerns and its effects on serotonin receptors.  |
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VII. Psychological Effects
25I-NBOMe is a potent hallucinogen affecting serotonin receptors, leading to vivid visual hallucinations and altered perception. Immediate effects include intense euphoria and sensory distortions, lasting several hours. Long-term use may result in persistent psychological effects and altered cognition. Research emphasizes its high potency and risks of severe psychological effects and persistent hallucinations.
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VIII. Culture
2-(4-Iodo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine, also known as 25I-NBOMe, is a synthetic psychedelic with no historical or cultural lore. It gained attention in modern times for its potent hallucinogenic effects and is used recreationally in the psychedelic drug community. Discussions focus on its safety, legal status, and potential for therapeutic use. Proponents highlight its intense psychedelic experiences, while opponents warn of health risks and potential for overdose. Its cultural significance lies in the evolving conversation about synthetic psychedelics, their effects, and regulation challenges.
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