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Name: 4-Anilino-N-phenethyl-4-piperidine (ANPP)
Type:
AKA: ANPP, Despropionyl fentanyl
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II. Natural Derivative
Synthetic substance, no natural derivative
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III. Chemical Profile (IUPAC name)
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IV. History
4-Anilino-N-Phenethyl-4-Piperidine (ANPP) is a precursor in the synthesis of fentanyl and other opioids. It has been studied since the 20th century for its role in opioid synthesis and drug development.
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V. Legal Information
4-Anilino-N-phenethyl-4-piperidine (ANPP) is an intermediate in the synthesis of fentanyl analogs. It is controlled due to its role in illicit drug production and its potential for misuse. [Source: UNODC].
US Federal Schedule - II
Schedule II drugs, substances, or chemicals are defined as drugs with a high potential for abuse, with use potentially leading to severe psychological or physical dependence. These drugs are also considered dangerous. Some examples of Schedule II drugs are: combination products with less than 15 milligrams of hydrocodone per dosage unit (Vicodin), cocaine, methamphetamine, methadone, hydromorphone (Dilaudid), meperidine (Demerol), oxycodone (OxyContin), fentanyl, Dexedrine, Adderall, and Ritalin.
Key US Federal Policies:
Controlled Substances Act. Public Law: Public Law 91-513 (text can be found on GovInfo) (https://www.dea.gov/drug-information/csa). Date enacted: October 27, 1970.
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VI. Physical Effects
4-Anilino-N-phenethylpiperidine (ANPP) is a precursor in the synthesis of fentanyl. It acts as a central nervous system stimulant and can affect heart rate and blood pressure. Short-term use in synthesis is controlled, but misuse can lead to severe health issues. Overdose risks include respiratory depression. Safe use involves strict control in manufacturing. Recent research focuses on its role in fentanyl synthesis and associated risks.  |
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VII. Psychological Effects
ANPP, an opioid precursor, affects mood and cognition. Immediate effects include euphoria and pain relief. Long-term use can result in dependence, tolerance, and cognitive impairments. Chronic use is associated with mood disorders and cognitive decline. Recent research emphasizes its potent effects and psychological risks associated with opioid use.
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VIII. Culture
4-Anilino-N-Phenethyl-4-Piperidine (ANPP) is a chemical precursor in the synthesis of fentanyl and its analogs. It has no cultural lore or historical significance but is crucial in modern discussions about the opioid crisis. Its role in the production of synthetic opioids highlights the challenges of regulating precursor chemicals. Modern cultural impact focuses on its place in the opioid epidemic, with proponents of strict regulation emphasizing its potential for misuse and opponents warning of the impact on legitimate pharmaceutical production. Its use is industrial, primarily for synthesizing opioids.
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