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Name: 4-Fluoroisobutyryl fentanyl (N-(4-fluorophenyl)-N-(1-phenethylpiperidin-4-yl)isobutyramide)
Type:
AKA: Para-fluoroisobutyryl fentanyl
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II. Natural Derivative
Synthetic substance, no natural derivative
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III. Chemical Profile (IUPAC name)
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IV. History
4-Fluoroisobutyryl fentanyl, a synthetic opioid, emerged in the 2010s as part of a new wave of potent fentanyl analogs. It was developed to mimic the effects of fentanyl, a powerful opioid analgesic, while incorporating fluorine to enhance its potency. The substance's appearance in the illicit drug market was part of a broader trend of synthetic opioids gaining popularity due to their high potency and lower production costs. Its use has been associated with a significant increase in opioid overdoses, prompting regulatory actions to control its distribution.
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V. Legal Information
4-Fluoroisobutyryl Fentanyl is a synthetic opioid with a high potential for abuse. It is classified as a Schedule I controlled substance in the United States due to its powerful effects and risk of addiction. Similar controls are enforced globally to curb its misuse and protect public health. [Source: UNODC].
US Federal Schedule - I
Schedule I drugs, substances, or chemicals are defined as drugs with no currently accepted medical use and a high potential for abuse. Some examples of Schedule I drugs are: heroin, lysergic acid diethylamide (LSD), marijuana (cannabis), 3,4-methylenedioxymethamphetamine (ecstasy), methaqualone, and peyote.
Key US Federal Policies:
Controlled Substances Act. Public Law: Public Law 91-513 (text can be found on GovInfo) (https://www.dea.gov/drug-information/csa). Date enacted: October 27, 1970.
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VI. Physical Effects
4-Fluoroisobutyryl fentanyl is a potent synthetic opioid with high analgesic potency. It acts as a downer, causing significant sedation and respiratory depression. Short-term use provides pain relief, but long-term use can lead to addiction and tolerance. Overdose risks include severe respiratory depression and potential death. Safe use requires strict dosing and medical supervision. Recent studies are investigating its potency and risks relative to other opioids.  |
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VII. Psychological Effects
4-Fluoroisobutyryl fentanyl is a potent synthetic opioid with effects similar to fentanyl. It provides intense euphoria, pain relief, and sedation. Immediate effects include mood elevation and significant cognitive impairment. Long-term use can lead to severe dependence, tolerance, and withdrawal symptoms. Chronic use is associated with mood disorders, cognitive decline, and high overdose risk. Recent research highlights its potency and severe psychological impacts.
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VIII. Culture
4-Fluoroisobutyryl fentanyl is a synthetic opioid with potent effects. Its cultural significance is associated with its role in the opioid crisis and the risks of synthetic opioids. Media coverage often addresses its potential for overdose and addiction. 4-Fluoroisobutyryl fentanyl is used recreationally rather than medicinally and contributes to discussions about opioid use and harm reduction.
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