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Name: 5-androstenedione (androst-5-en-3,17-dione)
Type: Androgenic steroid
AKA: N/A
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II. Natural Derivative
Synthetic substance, no natural derivative
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III. Chemical Profile (IUPAC name)
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IV. History
5-Androstenedione is a naturally occurring steroid hormone and a precursor to testosterone and estrogen. It has been used as a dietary supplement to enhance athletic performance and muscle growth. The use of androstenedione in sports has been controversial, leading to its regulation and ban by many sports organizations and regulatory bodies.
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V. Legal Information
5-Androstenedione, a steroid hormone and precursor to testosterone, is classified as a controlled substance in many jurisdictions due to its potential for misuse in sports and bodybuilding. In the US, it was formerly classified as a Schedule III controlled substance but is now regulated under the Anabolic Steroid Control Act. Globally, its status varies, with increasing controls reflecting concerns about performance enhancement and health risks.
US Federal Schedule - III
Schedule III drugs, substances, or chemicals are defined as drugs with a moderate to low potential for physical and psychological dependence. Schedule III drugs abuse potential is less than Schedule I and Schedule II drugs but more than Schedule IV. Some examples of Schedule III drugs are: products containing less than 90 milligrams of codeine per dosage unit (Tylenol with codeine), ketamine, anabolic steroids, testosterone.
Key US Federal Policies:
Controlled Substances Act. Public Law: Public Law 91-513 (text can be found on GovInfo) (https://www.dea.gov/drug-information/csa). Date enacted: October 27, 1970.
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VI. Physical Effects
5-Androstenedione, an anabolic steroid precursor, is used to enhance muscle growth. As an upper, it increases muscle mass and strength. Short-term effects include improved physical performance, while long-term use can lead to cardiovascular issues, liver damage, and hormonal imbalances. Overdose risks involve severe health complications. Safe use requires medical supervision. Recent research focuses on its effectiveness for muscle growth and the associated health risks.  |
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VII. Psychological Effects
5-Androstenedione, an anabolic steroid precursor, affects brain regions related to aggression and mood. Psychological effects include mood swings and aggression. Long-term use can lead to significant mental health issues and cognitive impairments. Research examines its impact on mental health and overall hormonal balance.
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VIII. Culture
5-Androstenedione is a steroid precursor used to increase testosterone levels, classifying it as an upper. Short-term use enhances muscle mass and energy, while long-term use may lead to hormonal imbalances, liver damage, and cardiovascular issues. Overdose risks include severe hormonal disruption and liver toxicity. Safe usage involves dosages typically under 100 mg per day with medical supervision. Recent findings highlight potential health risks and limited benefits. Physical effects include increased muscle mass and potential hormonal side effects.
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