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Name: Alfentanil
Type: Opioid analgesic
AKA: Alfenta
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II. Natural Derivative
Synthetic substance, no natural derivative
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III. Chemical Profile (IUPAC name)
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IV. History
Alfentanil, a potent opioid analgesic, was developed in the 1970s by Janssen Pharmaceutica. It is used for its rapid onset and short duration of action, making it suitable for use during surgery and anesthesia. Alfentanil is known for its effectiveness in pain management and has been used in various medical and surgical settings.
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V. Legal Information
Alfentanil, a potent synthetic opioid, is classified as a Schedule II controlled substance in the US due to its high potential for abuse. Globally, it faces similar restrictions reflecting its use in medical settings for pain management while preventing misuse.
US Federal Schedule - II
Schedule II drugs, substances, or chemicals are defined as drugs with a high potential for abuse, with use potentially leading to severe psychological or physical dependence. These drugs are also considered dangerous. Some examples of Schedule II drugs are: combination products with less than 15 milligrams of hydrocodone per dosage unit (Vicodin), cocaine, methamphetamine, methadone, hydromorphone (Dilaudid), meperidine (Demerol), oxycodone (OxyContin), fentanyl, Dexedrine, Adderall, and Ritalin.
Key US Federal Policies:
Controlled Substances Act. Public Law: Public Law 91-513 (text can be found on GovInfo) (https://www.dea.gov/drug-information/csa). Date enacted: October 27, 1970.
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VI. Physical Effects
Alfentanil, a potent opioid analgesic, is used for pain management and anesthesia. As a downer, it causes significant sedation and respiratory depression. Short-term effects include pain relief and euphoria, while long-term use can lead to tolerance and dependence. Overdose risks involve severe respiratory depression and potential fatality. Safe dosing requires precise medical supervision. Recent research highlights its high potency and role in controlled clinical settings.  |
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VII. Psychological Effects
Alfentanil, a potent opioid, affects opioid receptors, leading to intense euphoria and analgesia. Psychological effects include mood swings and potential cognitive issues. Immediate effects last several hours, with long-term use posing risks of dependence and significant mental health problems. Research examines its potency, abuse potential, and overall safety.
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VIII. Culture
Alfentanil, a potent synthetic opioid, is used for its rapid onset and short duration of action in anesthesia and pain management. Its cultural significance is tied to its role in modern anesthesia practices and the broader issues of opioid use. Alfentanil represents the ongoing efforts to balance effective pain relief with the risks of dependency and misuse. Its role in the cultural narrative is one of advancing anesthesia and pain management techniques while addressing the challenges of opioid use.
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