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Name: Clonitazene
Type: Opioid analgesic
AKA: N/A
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II. Natural Derivative
Synthetic substance, no natural derivative
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III. Chemical Profile (IUPAC name)
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IV. History
Clonitazene is a synthetic opioid developed in the 1950s. It is part of the benzimidazole class of opioids. Clonitazene has analgesic properties but is not widely used in medical practice due to the availability of other opioids with more favorable profiles. Its development contributed to the understanding and advancement of synthetic opioid analgesics.
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V. Legal Information
Clonitazene is a synthetic opioid that is often regulated under analog acts due to its similarity to controlled opioids. In the US, it may be covered under the Federal Analogue Act if considered similar to Schedule I or II substances. Globally, its legal status varies, with increasing restrictions reflecting concerns about synthetic opioids and their potential for abuse and harm.
US Federal Schedule - I
Schedule I drugs, substances, or chemicals are defined as drugs with no currently accepted medical use and a high potential for abuse. Some examples of Schedule I drugs are: heroin, lysergic acid diethylamide (LSD), marijuana (cannabis), 3,4-methylenedioxymethamphetamine (ecstasy), methaqualone, and peyote.
Key US Federal Policies:
Controlled Substances Act. Public Law: Public Law 91-513 (text can be found on GovInfo) (https://www.dea.gov/drug-information/csa). Date enacted: October 27, 1970.
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VI. Physical Effects
Clonitazene, a potent opioid analgesic, is used for severe pain relief. As a downer, it causes significant sedation and respiratory depression. Short-term effects include pain relief and euphoria, while long-term use can lead to addiction, tolerance, and overdose. Overdose risks involve severe respiratory depression and potential fatality. Safe dosing is critical, often starting at very low amounts. Recent studies focus on its high potency and associated risks, emphasizing the need for careful medical supervision.  |
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VII. Psychological Effects
Clonitazene, a synthetic opioid, affects opioid receptors, leading to euphoria and sedation. Psychological effects include altered mood and potential cognitive deficits. Long-term use carries risks of dependence and severe mental health issues. Research focuses on its potency and impact on mental health.
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VIII. Culture
Clonitazene, an opioid analgesic, emerged in the mid-20th century. Though it has not gained significant cultural prominence, it is part of the broader opioid narrative involving pain management and addiction. Its cultural significance is largely tied to the medical community’s efforts to find effective pain relief solutions while mitigating the risks of dependency and misuse. The substance exemplifies the challenges faced in opioid pharmacotherapy, highlighting the balance between therapeutic benefits and potential for abuse. Clonitazene remains a lesser-known but relevant player in the ongoing opioid discourse.
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