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Name: Clorazepate
Type: Benzodiazepine
AKA: Tranxene
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II. Natural Derivative
Synthetic substance, no natural derivative
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III. Chemical Profile (IUPAC name)
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IV. History
Clorazepate, a benzodiazepine, was first developed in the 1960s. It was introduced for its anxiolytic and sedative effects. The compound became a widely used medication for anxiety and other conditions. Clorazepate's introduction reflected advancements in benzodiazepine therapy, but its use has been associated with dependence and regulatory controls.
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V. Legal Information
Clorazepate, a benzodiazepine, is classified as a Schedule IV controlled substance in the US, allowing limited medical use. It is similarly regulated in many countries due to its potential for abuse and dependency. The UNODC emphasizes the need for balanced regulation to ensure safe medical use while preventing misuse. Trends indicate ongoing control measures to monitor and regulate benzodiazepines.
US Federal Schedule - IV
Schedule IV drugs, substances, or chemicals are defined as drugs with a low potential for abuse and low risk of dependence. Some examples of Schedule IV drugs are: Xanax, Soma, Darvon, Darvocet, Valium, Ativan, Talwin, Ambien, Tramadol.
Key US Federal Policies:
Controlled Substances Act. Public Law: Public Law 91-513 (text can be found on GovInfo) (https://www.dea.gov/drug-information/csa). Date enacted: October 27, 1970.
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VI. Physical Effects
Clorazepate is a benzodiazepine that produces sedation and reduces anxiety. It can cause drowsiness, decreased heart rate, and muscle relaxation. Short-term effects include anxiety reduction and improved sleep, while long-term use may lead to dependence, tolerance, and cognitive impairment. Overdose risks include severe sedation, respiratory depression, and potential death. Safe dosing requires careful medical oversight. Recent research emphasizes its benefits in anxiety treatment and the risks of long-term use.  |
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VII. Psychological Effects
A benzodiazepine used for anxiety with sedative effects. Long-term use can lead to dependence, cognitive impairment, and mood disturbances. Research highlights its impact on GABA receptors and risks of psychological dependence.
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VIII. Culture
Clorazepate, a benzodiazepine, is used to treat anxiety, seizures, and alcohol withdrawal symptoms. Benzodiazepines have a long history of use in managing mental health conditions, reflecting evolving societal attitudes towards psychiatric treatment and pharmaceutical intervention. In modern culture, clorazepate and other benzodiazepines are both praised for their therapeutic benefits and criticized for their potential for dependence and abuse. Clorazepate's role in mental health treatment underscores broader conversations about the balance between effective medication and the risks of long-term use. Media discussions often highlight personal stories of dependence, contributing to ongoing debates about mental health care and the ethics of psychiatric medication.
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