|
Name: Difenoxin
Type: Antidiarrheal
AKA: Lyspafen
|
|
II. Natural Derivative
Synthetic substance, no natural derivative
 |
|
III. Chemical Profile (IUPAC name)
|
|
IV. History
Difenoxin, a synthetic opioid, was developed in the 1960s as a treatment for diarrhea. It is often used in combination with atropine to prevent misuse. Its effectiveness in gastrointestinal treatments has made it a common component in anti-diarrheal medications.
|
|
V. Legal Information
Difenoxin, used to treat diarrhea, is regulated as a controlled substance due to its potential for abuse. Its status reflects efforts to manage opioid use and prevent misuse.
US Federal Schedule - I
Schedule I drugs, substances, or chemicals are defined as drugs with no currently accepted medical use and a high potential for abuse. Some examples of Schedule I drugs are: heroin, lysergic acid diethylamide (LSD), marijuana (cannabis), 3,4-methylenedioxymethamphetamine (ecstasy), methaqualone, and peyote.
Key US Federal Policies:
Controlled Substances Act. Public Law: Public Law 91-513 (text can be found on GovInfo) (https://www.dea.gov/drug-information/csa). Date enacted: October 27, 1970.
|
|
VI. Physical Effects
Difenoxin is an antidiarrheal agent that reduces gastrointestinal motility. As a downer, it helps manage diarrhea and gastrointestinal issues. Short-term effects include reduced bowel movements, while long-term use may lead to dependency and tolerance. Overdose risks involve severe gastrointestinal issues. Safe dosing typically ranges from 0.5-1 mg daily. Recent research highlights its effectiveness and potential risks.  |
|
VII. Psychological Effects
Difenoxin, an opioid, affects opioid receptors to provide analgesia and mood alteration. Immediate effects include euphoria and cognitive impairment, with long-term use potentially causing dependence and psychological issues such as depression. Effects last several hours, with risks of significant mental health issues with chronic use.
 |
|
VIII. Culture
Difenoxin is an opioid used as an anti-diarrheal with no historical lore. It emerged in the 20th century as a treatment for diarrhea and is known for its effectiveness and potential for misuse. Its cultural impact is tied to discussions about opioid regulation and treatment of gastrointestinal issues. Proponents emphasize its therapeutic use, while opponents raise concerns about addiction and misuse.
 |