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Name: Difenoxin preparations - 0.5 mg/25 ug AtSO4/du
Type: Antidiarrheal
AKA: Motofen
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II. Natural Derivative
Synthetic substance, no natural derivative
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III. Chemical Profile (IUPAC name)
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IV. History
Difenoxin preparations, developed in the 1970s, are used to treat diarrhea. It is an opioid antidiarrheal agent with similar properties to diphenoxylate, though its use has declined with the advent of newer treatments.
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V. Legal Information
Difenoxin preparations, used to treat diarrhea, are regulated as controlled substances due to their potential for abuse. Their status reflects efforts to manage opioid use and prevent misuse.
US Federal Schedule - V
Schedule V drugs, substances, or chemicals are defined as drugs with lower potential for abuse than Schedule IV and consist of preparations containing limited quantities of certain narcotics. Schedule V drugs are generally used for antidiarrheal, antitussive, and analgesic purposes. Some examples of Schedule V drugs are: cough preparations with less than 200 milligrams of codeine or per 100 milliliters (Robitussin AC), Lomotil, Motofen, Lyrica, Parepectolin.
Key US Federal Policies:
Controlled Substances Act. Public Law: Public Law 91-513 (text can be found on GovInfo) (https://www.dea.gov/drug-information/csa). Date enacted: October 27, 1970.
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VI. Physical Effects
Difenoxin is an antidiarrheal agent that reduces gastrointestinal motility. As a downer, it helps manage diarrhea and gastrointestinal issues. Short-term effects include reduced bowel movements, while long-term use may lead to dependency and tolerance. Overdose risks involve severe gastrointestinal issues. Safe dosing typically ranges from 0.5-1 mg daily. Recent research highlights its effectiveness and potential risks.  |
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VII. Psychological Effects
Difenoxin, an opioid, affects opioid receptors to provide analgesia and mood alteration. Immediate effects include euphoria and cognitive impairment, while long-term use can lead to dependence and psychological issues such as depression. Effects last several hours, with chronic use linked to significant mental health issues and cognitive decline.
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VIII. Culture
Difenoxin preparations, including those with 0.5 mg dosage, are used for treating diarrhea. They have no historical lore but gained attention in the 20th century for their medicinal use. Cultural significance includes discussions about opioid-based treatments and potential misuse. Proponents value their effectiveness, while opponents focus on addiction risks.
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