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Name: Dihydroetorphine
Type: Opioid
AKA: DHE
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II. Natural Derivative
Synthetic substance, no natural derivative
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IV. History
Dihydroetorphine, a potent opioid analgesic, was developed in the mid-20th century. It is used primarily for pain management in clinical settings. Its history reflects its development as a powerful alternative to other opioids, with attention to its potency and addiction potential.
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V. Legal Information
Dihydroetorphine is a potent opioid used for pain relief in some countries but is tightly controlled due to its high potential for abuse. In the U.S., it is regulated under opioid laws similar to other strong narcotics. Internationally, its control reflects broader efforts to manage opioid use and prevent misuse. [Source: UNODC].
US Federal Schedule - II
Schedule II drugs, substances, or chemicals are defined as drugs with a high potential for abuse, with use potentially leading to severe psychological or physical dependence. These drugs are also considered dangerous. Some examples of Schedule II drugs are: combination products with less than 15 milligrams of hydrocodone per dosage unit (Vicodin), cocaine, methamphetamine, methadone, hydromorphone (Dilaudid), meperidine (Demerol), oxycodone (OxyContin), fentanyl, Dexedrine, Adderall, and Ritalin.
Key US Federal Policies:
Controlled Substances Act. Public Law: Public Law 91-513 (text can be found on GovInfo) (https://www.dea.gov/drug-information/csa). Date enacted: October 27, 1970.
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VI. Physical Effects
Dihydroetorphine is a potent opioid analgesic that induces strong pain relief and sedation. It can cause constricted pupils, reduced heart rate, and respiratory depression. Short-term effects include effective pain management, while long-term use may lead to addiction and respiratory issues. Overdose risks involve severe respiratory depression. Safe use requires medical oversight. Recent research highlights its potency and associated risks.  |
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VII. Psychological Effects
Dihydroetorphine, an opioid, affects mu-opioid receptors, leading to strong analgesia and mood elevation. Immediate effects include euphoria and sedation, lasting several hours. Long-term use can result in addiction, cognitive impairments, and mood disturbances. Recent studies focus on its potency and the associated risks of psychological dependence and cognitive effects.
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VIII. Culture
Dihydroetorphine is a potent opioid used primarily in veterinary medicine. It has no historical lore but gained significance in the late 20th century for its role in managing pain in animals. Its cultural impact is related to its potency compared to other opioids. Proponents highlight its effectiveness in veterinary care, while opponents caution about its potential misuse and safety. Its use is strictly medicinal, particularly in animal care.
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