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Name: Fospropofol
Type: Anesthetic
AKA: Lusedra
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II. Natural Derivative
Synthetic substance, no natural derivative
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III. Chemical Profile (IUPAC name)
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IV. History
Fospropofol, a prodrug of propofol, was introduced in the 2000s. It is used for sedation and anesthesia, providing a more controlled release of propofol. The development of fospropofol aimed to improve patient safety and comfort during procedures.
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V. Legal Information
Fospropofol, a prodrug of propofol used in anesthesia, is regulated due to its potential for misuse. Its legal status varies by jurisdiction, reflecting efforts to manage its use in medical settings.
US Federal Schedule - IV
Schedule IV drugs, substances, or chemicals are defined as drugs with a low potential for abuse and low risk of dependence. Some examples of Schedule IV drugs are: Xanax, Soma, Darvon, Darvocet, Valium, Ativan, Talwin, Ambien, Tramadol.
Key US Federal Policies:
Controlled Substances Act. Public Law: Public Law 91-513 (text can be found on GovInfo) (https://www.dea.gov/drug-information/csa). Date enacted: October 27, 1970.
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VI. Physical Effects
Fospropofol is a prodrug of propofol used for sedation and anesthesia. It acts as a downer, causing sedation and reduced consciousness. Short-term use is effective for procedural sedation, but long-term use or excessive dosing can lead to respiratory depression and cardiovascular issues. Safe use involves careful dosing and monitoring. Recent studies focus on its efficacy in sedation and safety profile compared to other anesthetics.  |
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VII. Psychological Effects
Fospropofol, a sedative-hypnotic, affects GABA-A receptors to provide sedation. Immediate effects include relaxation and cognitive impairment, with long-term use potentially leading to dependence and cognitive decline. Research examines its use in sedation and potential psychological impacts.
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VIII. Culture
Fospropofol is a prodrug of propofol used for sedation. It has no significant historical or cultural lore but gained importance in the late 20th century for its medical applications. Discussions focus on its benefits in procedural sedation versus potential side effects. Proponents highlight its effectiveness in sedation, while opponents point to risks and potential misuse. Its use is strictly medicinal, reflecting broader themes in anesthesia and sedation practices.
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