Name:
Glutethimide
Type:
Sedative
AKA:
Doriden, Dorimide
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Synthetic substance, no natural derivative
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Glutethimide image
Glutethimide is a hypnotic and sedative drug that was first introduced in the 1950s as a treatment for insomnia. It was marketed under the brand name Doriden. Glutethimide acts as a central nervous system depressant, similar to barbiturates. Due to its potential for abuse and dependence, glutethimide's use declined over the years, and it has been largely replaced by safer alternatives like benzodiazepines.
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Glutethimide, a sedative-hypnotic, is used for its calming effects. As a downer, it induces sedation and muscle relaxation. Short-term effects include drowsiness and reduced anxiety, while long-term use can lead to dependence and cognitive issues. Overdose risks include severe sedation, respiratory depression, and potentially death. Safe use involves adhering to prescribed doses, typically 250-500 mg. Recent research highlights its use in treating insomnia but also notes the risks of abuse and potential dependence.
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Glutethimide, a sedative-hypnotic, impacts GABA-A receptors, leading to reduced anxiety and sedation. Psychological effects include impaired cognition and mood changes. Long-term use can result in dependence and significant cognitive issues. Research focuses on its historical use, abuse potential, and impact on mental health.
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Glutethimide, a sedative-hypnotic drug introduced in the mid-20th century, was initially used as an alternative to barbiturates for treating insomnia. Its cultural significance lies in its representation of the shifting trends in pharmacotherapy for sleep disorders. However, like many sedatives, glutethimide’s potential for abuse and addiction became apparent, leading to its decline in medical use. The substance is part of the broader narrative of the search for effective and safe treatments for insomnia and anxiety. Glutethimide’s legacy is a cautionary tale of the unintended consequences of sedative use and the ongoing challenges in managing sleep and anxiety disorders.
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