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Name: Isomethadone
Type: Opioid
AKA: Isoamidone
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II. Natural Derivative
Synthetic substance, no natural derivative
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III. Chemical Profile (IUPAC name)
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IV. History
Isomethadone, a synthetic opioid, was developed in the mid-20th century. It is used for its analgesic properties and represents an important advancement in opioid medication research.
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V. Legal Information
Isomethadone, a synthetic opioid, is classified as a Schedule II controlled substance in the US, reflecting its high potential for abuse and limited medical use. Globally, it is subject to similar controls, with strict regulations on its distribution and use. The UNODC emphasizes the importance of monitoring and controlling synthetic opioids to combat the opioid crisis, with ongoing efforts towards stricter regulation.
US Federal Schedule - II
Schedule II drugs, substances, or chemicals are defined as drugs with a high potential for abuse, with use potentially leading to severe psychological or physical dependence. These drugs are also considered dangerous. Some examples of Schedule II drugs are: combination products with less than 15 milligrams of hydrocodone per dosage unit (Vicodin), cocaine, methamphetamine, methadone, hydromorphone (Dilaudid), meperidine (Demerol), oxycodone (OxyContin), fentanyl, Dexedrine, Adderall, and Ritalin.
Key US Federal Policies:
Controlled Substances Act. Public Law: Public Law 91-513 (text can be found on GovInfo) (https://www.dea.gov/drug-information/csa). Date enacted: October 27, 1970.
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VI. Physical Effects
Isomethadone is a methadone analog used for pain management. It acts as a downer, causing sedation and respiratory depression. Short-term use provides pain relief, but long-term use can lead to addiction and tolerance. Overdose risks include severe respiratory depression and potential death. Safe use requires precise dosing and medical supervision. Recent research investigates its efficacy and safety compared to methadone.  |
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VII. Psychological Effects
Isomethadone, a synthetic opioid, affects mu-opioid receptors, leading to euphoria, pain relief, and sedation. Immediate effects include mood enhancement and analgesia, lasting several hours. Long-term use may result in addiction, cognitive impairments, and mood disturbances. Research emphasizes its potential for dependence and its impact on opioid receptors, affecting neurotransmitter systems related to reward and pain.
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VIII. Culture
Isomethadone is a synthetic opioid analgesic providing pain relief, classifying it as a downer. Short-term use alleviates severe pain, while long-term use can lead to dependence and tolerance. Overdose is highly possible, causing respiratory depression and potentially fatal outcomes. Safe dosages are medically prescribed, typically under 100 mg per day. Recent research highlights its efficacy in pain management but warns of addiction risks. Physical effects include drowsiness, constricted pupils, and respiratory depression.
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