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Name: JWH-398 (1-Pentyl-3-(4-chloro-1-naphthoyl)indole)
Type: Synthetic cannabinoid
AKA: JWH-398
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II. Natural Derivative
Synthetic substance, no natural derivative
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III. Chemical Profile (IUPAC name)
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IV. History
JWH-398, a synthetic cannabinoid, was first synthesized in the early 2000s. It is part of the JWH series and was developed for its high potency and interaction with cannabinoid receptors. The compound appeared in synthetic cannabis products and gained attention for its psychoactive effects. JWH-398's potency and health risks have led to regulatory controls.
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V. Legal Information
JWH-398, a synthetic cannabinoid, is illegal in the US as a Schedule I substance. Many countries have banned it due to its psychoactive effects and health risks. The UNODC monitors synthetic cannabinoids, highlighting the need for international control to prevent abuse. Regulatory trends focus on stricter enforcement and penalties to address the growing concern of synthetic cannabinoid use.
US Federal Schedule - I
Schedule I drugs, substances, or chemicals are defined as drugs with no currently accepted medical use and a high potential for abuse. Some examples of Schedule I drugs are: heroin, lysergic acid diethylamide (LSD), marijuana (cannabis), 3,4-methylenedioxymethamphetamine (ecstasy), methaqualone, and peyote.
Key US Federal Policies:
Controlled Substances Act. Public Law: Public Law 91-513 (text can be found on GovInfo) (https://www.dea.gov/drug-information/csa). Date enacted: October 27, 1970.
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VI. Physical Effects
JWH-398 is a synthetic cannabinoid that acts as an upper, producing psychoactive effects similar to cannabis. Short-term use can lead to altered perception and euphoria, while long-term effects are not well understood. Overdose risks include severe psychological distress and potential toxicity. Safe use is uncertain due to limited research. Recent studies focus on its psychoactive properties and associated health risks.  |
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VII. Psychological Effects
JWH-398, a synthetic cannabinoid, affects cannabinoid receptors, causing altered mood and perception. Immediate effects include euphoria and relaxation, with long-term use potentially leading to cognitive impairments and psychological issues. Research examines its potency and psychological impact.
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VIII. Culture
JWH-398 is a synthetic cannabinoid with effects similar to THC, classifying it as a downer. Short-term use induces euphoria and relaxation, while long-term use can lead to cognitive impairment and psychological dependence. Overdose risks include severe anxiety, hallucinations, and cardiovascular issues. Safe dosages are not well-established, with lower doses advised. Recent research highlights its high abuse potential and significant health risks. Physical effects include red eyes, dry mouth, and altered mental state.
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