Phyllomedusin

Kambo has been used traditionally by indigenous peoples of the Amazon Basin for its purgative and stimulating effects. It is applied to the skin in a ritualistic ceremony.

Kambo application can cause a variety of physical responses, including intense nausea, vomiting, and increased heart rate. The effects are generally short-lived but can be quite intense. Long-term physical effects are not well-documented, but the substance is known for its strong purgative action.

Kambo's psychological effects include altered perceptions and heightened emotional responses during and after the purge. The experience can be intense and challenging, often accompanied by a sense of spiritual or emotional cleansing. Long-term psychological impacts are less understood.

Kambo is traditionally used by indigenous tribes in the Amazon as part of purification rituals and spiritual practices. The ceremony is often performed by a shaman and involves the application of Kambo to small burns on the skin, leading to a strong purgative effect.