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Name: Lacosamide
Type: Anticonvulsant
AKA: Vimpat
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II. Natural Derivative
Synthetic substance, no natural derivative
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III. Chemical Profile (IUPAC name)
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IV. History
Lacosamide is an antiepileptic drug that was first approved by the FDA in 2008. Developed by UCB, it is used to treat partial-onset seizures in patients with epilepsy. Lacosamide works by selectively enhancing slow inactivation of voltage-gated sodium channels, stabilizing hyperexcitable neuronal membranes. Its introduction provided a new option for patients with epilepsy, particularly those who did not respond well to other treatments.
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V. Legal Information
Lacosamide is an anticonvulsant medication that is not classified as a controlled substance in the US. It is used to treat epilepsy and is available by prescription. Globally, its legal status is similar, with no significant restrictions affecting its availability. The drug is regulated as a pharmaceutical product rather than a controlled substance, reflecting its medical use and safety profile.
US Federal Schedule - V
Schedule V drugs, substances, or chemicals are defined as drugs with lower potential for abuse than Schedule IV and consist of preparations containing limited quantities of certain narcotics. Schedule V drugs are generally used for antidiarrheal, antitussive, and analgesic purposes. Some examples of Schedule V drugs are: cough preparations with less than 200 milligrams of codeine or per 100 milliliters (Robitussin AC), Lomotil, Motofen, Lyrica, Parepectolin.
Key US Federal Policies:
Controlled Substances Act. Public Law: Public Law 91-513 (text can be found on GovInfo) (https://www.dea.gov/drug-information/csa). Date enacted: October 27, 1970.
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VI. Physical Effects
Lacosamide, an anticonvulsant, is used to manage epilepsy. As a downer, it stabilizes electrical activity in the brain, reducing seizure frequency. Short-term effects include improved seizure control and reduced anxiety, while long-term use is generally considered safe with minimal risks. Overdose risks include dizziness and potential heart rhythm issues. Safe dosage ranges from 100-400 mg daily. Recent findings confirm its efficacy in treating seizures but also stress the importance of monitoring for possible side effects and interactions.  |
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VII. Psychological Effects
Lacosamide, an anticonvulsant, affects sodium channels in the brain, stabilizing neuronal activity. Psychological effects include reduced seizure frequency and improved mood stability. It can cause cognitive impairments with long-term use. Research is ongoing into its effectiveness for epilepsy and potential cognitive side effects.
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VIII. Culture
Lacosamide, an antiepileptic drug, has been used since the early 21st century to treat partial-onset seizures. Its cultural significance is primarily within the medical community, representing advancements in the treatment of epilepsy. The substance highlights the ongoing efforts to improve the quality of life for individuals with seizure disorders. While it lacks the widespread cultural impact of other substances, lacosamide is an important part of the narrative of modern medicine and the development of more effective and targeted treatments for neurological conditions. The drug is a symbol of progress in the field of epilepsy research and treatment.
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