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Name: Lemborexant
Type: Orexin receptor antagonist
AKA: ['(1R', '2S)-2-[(2', '4-dimethylpyrimidin-5-yl)oxymethyl]-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl)cyclopropane-1-carboxamide']
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II. Natural Derivative
Synthetic substance, no natural derivative
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IV. History
Lemborexant, a selective orexin receptor antagonist, was developed in the 21st century. It is used to treat insomnia and works by regulating wakefulness and sleep. It represents a new class of medications for sleep disorders and is noted for its efficacy in promoting sleep without causing dependence.
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V. Legal Information
Lemborexant is a medication used to treat insomnia. It is controlled to manage its medical use and prevent misuse. [Source: UNODC].
US Federal Schedule - IV
Schedule IV drugs, substances, or chemicals are defined as drugs with a low potential for abuse and low risk of dependence. Some examples of Schedule IV drugs are: Xanax, Soma, Darvon, Darvocet, Valium, Ativan, Talwin, Ambien, Tramadol.
Key US Federal Policies:
Controlled Substances Act. Public Law: Public Law 91-513 (text can be found on GovInfo) (https://www.dea.gov/drug-information/csa). Date enacted: October 27, 1970.
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VI. Physical Effects
Lemborexant is a dual orexin receptor antagonist used for the treatment of insomnia. It causes drowsiness and reduced heart rate. Short-term use effectively promotes sleep, while long-term use may cause dependence and cognitive impairment. Overdose risks include excessive sedation and respiratory depression. Safe use involves adhering to prescribed doses. Recent research highlights its efficacy for sleep disorders and associated risks with prolonged use.  |
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VII. Psychological Effects
Lemborexant, a hypnotic, affects orexin receptors, causing sedation and mood alteration. Immediate effects include anxiety reduction and mood enhancement, lasting several hours. Long-term use can lead to dependence and psychological issues such as depression. Research indicates significant mental health risks with chronic use, including severe mood disturbances and potential for addiction.
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VIII. Culture
Lemborexant is a medication used for insomnia, classifying it as a downer. Short-term use promotes sleep and relaxation, while long-term use can lead to dependence and cognitive impairment. Overdose risks include severe sedation and respiratory depression. Safe dosages are typically prescribed by medical professionals. Recent research highlights its efficacy in treating insomnia but warns of potential side effects and dependence. Physical effects include drowsiness, impaired coordination, and potential for respiratory depression.
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