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Name: Methadone intermediate (4-cyano-2-dimethylamino-4,4-diphenylbutane)
Type: Opioid
AKA: Methadone precursor
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II. Natural Derivative
Synthetic substance, no natural derivative
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III. Chemical Profile (IUPAC name)
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IV. History
Methadone intermediate is a precursor used in the synthesis of methadone, a synthetic opioid used for pain management and as a treatment for opioid dependence. Methadone was first synthesized in the 1940s and has become a crucial medication in opioid substitution therapy. The intermediate compound is not used therapeutically but is essential in the production of methadone.
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V. Legal Information
Methadone intermediates, like 4-cyano-2-dimethylamino-4,4-diphenylbutane, are regulated due to their role in producing controlled substances. In the US, methadone and its precursors are classified under Schedule II. Globally, regulations aim to control the production of opioids and prevent misuse by regulating precursor chemicals.
US Federal Schedule - II
Schedule II drugs, substances, or chemicals are defined as drugs with a high potential for abuse, with use potentially leading to severe psychological or physical dependence. These drugs are also considered dangerous. Some examples of Schedule II drugs are: combination products with less than 15 milligrams of hydrocodone per dosage unit (Vicodin), cocaine, methamphetamine, methadone, hydromorphone (Dilaudid), meperidine (Demerol), oxycodone (OxyContin), fentanyl, Dexedrine, Adderall, and Ritalin.
Key US Federal Policies:
Controlled Substances Act. Public Law: Public Law 91-513 (text can be found on GovInfo) (https://www.dea.gov/drug-information/csa). Date enacted: October 27, 1970.
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VI. Physical Effects
Methadone Intermediate, used in methadone synthesis, is a potent opioid. As a downer, it causes significant sedation and respiratory depression. Short-term effects include pain relief and euphoria, while long-term use can lead to addiction and tolerance. Overdose risks involve severe respiratory depression and potential fatality. Safe use requires careful medical supervision. Recent research emphasizes its role in methadone production and the need for caution due to potency and addiction risks.  |
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VII. Psychological Effects
Methadone intermediate affects opioid receptors, leading to analgesia and mood alteration. Psychological effects include pain relief and potential cognitive effects. Long-term use can result in dependence and mental health issues. Research focuses on its role in opioid synthesis and its impact on mental health.
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VIII. Culture
Methadone intermediate (4-cyano-2-dimethylamino-4,4-diphenylbutane) is a precursor in methadone synthesis, classifying it as a downer. It is not used directly for therapeutic purposes but is crucial in methadone production. Methadone is used for pain relief and opioid dependence treatment, with short-term use providing analgesia, and long-term use potentially leading to dependence and health issues. Overdose risks include severe respiratory depression. Safe dosages for methadone are prescribed and controlled by medical professionals. Recent research emphasizes the importance of controlling intermediates to prevent misuse.
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