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Name: Methylone (3,4-Methylenedioxy-N-methylcathinone)
Type: Synthetic cathinone
AKA: ['(Positional Isomer: 2', '3methylenedioxymethcathinone (2', '3-MDMC', '1-(benzo[d][1', '3]dioxol-4-yl)-2-(methylamino)propan-1-one))', 'synthetic cathinones']
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II. Natural Derivative
Synthetic substance, no natural derivative
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III. Chemical Profile (IUPAC name)
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IV. History
In 1936, Dr. Eric N. Stoll of the University of Minnesota received a patent for a chemical that he claimed was an improved derivative of d-amphetamine. The patent was granted on September 30, 1936. He named the substance methylone.
The drug was a big success and was used as an anesthetic and a hypnotic. It was also used as a stimulant. The drug was so popular that Stoll was able to sell it for $1.50 per dose.
In 1947, Dr. Alfred N. Green and Dr. Walter Kiehn of the University of California patented the compound they called methylone. In 1949, Green and Kiehn began producing it on a commercial scale.
In 1952, Green and Kiehn began marketing the drug as an anesthetic.
In 1953, Green and Kiehn formed a partnership with the National Alco-Cola Company.
In 1956, Green and Kiehn formed a
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V. Legal Information
Methylone is a synthetic cathinone with stimulant and empathogenic effects. It is classified as a controlled substance due to its potential for abuse and is subject to increasing international regulation. [Source: UNODC].
US Federal Schedule - I
Schedule I drugs, substances, or chemicals are defined as drugs with no currently accepted medical use and a high potential for abuse. Some examples of Schedule I drugs are: heroin, lysergic acid diethylamide (LSD), marijuana (cannabis), 3,4-methylenedioxymethamphetamine (ecstasy), methaqualone, and peyote.
Key US Federal Policies:
Controlled Substances Act. Public Law: Public Law 91-513 (text can be found on GovInfo) (https://www.dea.gov/drug-information/csa). Date enacted: October 27, 1970.
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VI. Physical Effects
Methylone, a synthetic cathinone and member of the MDMA family, was first synthesized in the 1960s. It acts as an upper, producing effects similar to MDMA, including euphoria and increased energy. Physical impacts include increased heart rate, dilated pupils, and elevated blood pressure. Short-term use may cause anxiety, agitation, and dehydration, while long-term use can lead to serotonin depletion and cognitive deficits. Overdose risks include severe agitation, hyperthermia, and cardiovascular issues. Safe use involves cautious dosing, and recent research highlights its potential for abuse and its impact on serotonin levels.  |
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VII. Psychological Effects
Methylone is a stimulant and empathogen with effects similar to MDMA, causing euphoria and emotional openness. Long-term use may lead to mood disturbances and cognitive issues. Research highlights its impact on serotonin systems and associated risks.
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VIII. Culture
Methylone is a synthetic cathinone that has been used recreationally since the early 2000s. It is known for its empathogenic effects similar to MDMA. Its cultural significance includes its popularity in party and rave scenes. Proponents highlight its euphoric effects, while opponents caution about its safety and potential for addiction. Its use is primarily recreational, reflecting broader trends in psychoactive substance use.
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