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Name: Nalorphine
Type: Opioid
AKA: Nalline
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II. Natural Derivative
Synthetic substance, no natural derivative
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III. Chemical Profile (IUPAC name)
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IV. History
Nalorphine, first synthesized in the 1950s, is an opioid antagonist and partial agonist. It was used in the 1960s and 70s as a treatment for opioid overdose and dependence. Its development marked a significant advance in opioid addiction treatment, though it has largely been replaced by more effective agents like naloxone.
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V. Legal Information
Nalorphine, an opioid antagonist and partial agonist, is classified as a controlled substance in some jurisdictions due to its opioid effects. In the US, it is not widely used or regulated. Globally, its status varies, with some countries controlling it due to its potential for misuse.
US Federal Schedule - III
Schedule III drugs, substances, or chemicals are defined as drugs with a moderate to low potential for physical and psychological dependence. Schedule III drugs abuse potential is less than Schedule I and Schedule II drugs but more than Schedule IV. Some examples of Schedule III drugs are: products containing less than 90 milligrams of codeine per dosage unit (Tylenol with codeine), ketamine, anabolic steroids, testosterone.
Key US Federal Policies:
Controlled Substances Act. Public Law: Public Law 91-513 (text can be found on GovInfo) (https://www.dea.gov/drug-information/csa). Date enacted: October 27, 1970.
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VI. Physical Effects
Nalorphine, an opioid antagonist, is used to reverse opioid effects. As a downer, it can counteract opioid-induced sedation. Short-term effects include reduced sedation and respiratory depression, while long-term use is generally limited to specific medical scenarios. Overdose risks are minimal in controlled use. Safe dosing involves careful medical administration. Recent findings focus on its role in opioid overdose reversal and its effectiveness in emergency situations.  |
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VII. Psychological Effects
Nalorphine, an opioid antagonist, affects opioid receptors to block the effects of opioids. Psychological impacts include reduced euphoria and potential withdrawal symptoms. Immediate effects include diminished opioid effects, while long-term use may have limited psychological impacts. Research focuses on its role in opioid reversal and potential therapeutic uses.
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VIII. Culture
Nalorphine, an opioid antagonist, was used to counteract the effects of opioid overdose and manage pain. Its cultural significance is tied to its role in opioid pharmacotherapy and the broader issues of opioid use and overdose. Nalorphine reflects the challenges of managing opioid dependency and the development of treatments to address opioid-related crises. Its role in the cultural narrative is one of advancing medical treatments for opioid overdose and the ongoing efforts to address opioid misuse.
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