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Name: Norfentanyl (N-phenyl-N-(piperidin-4-yl)propionamide)
Type: Synthetic opioid
AKA: N/A
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II. Natural Derivative
Synthetic substance, no natural derivative
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III. Chemical Profile (IUPAC name)
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IV. History
Norfentanyl, a derivative of fentanyl, was developed in the 1970s as part of research into potent opioid analgesics. It is known for its high potency and has been used primarily in research settings. The development of norfentanyl and similar compounds has contributed to the understanding of opioid receptor interactions and the development of powerful analgesics.
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V. Legal Information
Norfentanyl, a potent synthetic opioid, is often regulated under analog laws due to its similarity to fentanyl. In the US, it could be covered under the Federal Analog Act if deemed similar to other controlled substances. Globally, its status is restrictive, reflecting efforts to manage opioid abuse and prevent misuse.
US Federal Schedule - II
Schedule II drugs, substances, or chemicals are defined as drugs with a high potential for abuse, with use potentially leading to severe psychological or physical dependence. These drugs are also considered dangerous. Some examples of Schedule II drugs are: combination products with less than 15 milligrams of hydrocodone per dosage unit (Vicodin), cocaine, methamphetamine, methadone, hydromorphone (Dilaudid), meperidine (Demerol), oxycodone (OxyContin), fentanyl, Dexedrine, Adderall, and Ritalin.
Key US Federal Policies:
Controlled Substances Act. Public Law: Public Law 91-513 (text can be found on GovInfo) (https://www.dea.gov/drug-information/csa). Date enacted: October 27, 1970.
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VI. Physical Effects
Norfentanyl, a synthetic opioid, is used for pain relief. As a downer, it induces significant sedation and respiratory depression. Short-term effects include pain relief and euphoria, while long-term use can lead to addiction and tolerance. Overdose risks involve severe respiratory issues and potential fatality. Safe dosing requires medical supervision. Recent findings focus on its potency and associated risks of addiction and overdose.  |
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VII. Psychological Effects
Norfentanyl, an opioid analog, binds to opioid receptors, producing strong euphoria and sedation. Immediate effects include mood alteration and cognitive impairment, with long-term use carrying risks of dependence and mental health issues. Research focuses on its potency, safety profile, and potential for abuse.
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VIII. Culture
Norfentanyl, a synthetic opioid, is known for its potent analgesic effects. Its cultural significance is linked to its role in opioid pharmacotherapy and the broader issues of opioid use. Norfentanyl reflects the ongoing challenges of managing pain while addressing risks of dependency and misuse. Its role in the cultural narrative is one of scientific and medical advancement in opioid treatments, highlighting the complexities of opioid medications in modern healthcare.
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