|
Name: ortho-Methyl acetylfentanyl (N-(2-methylphenyl)-N-(1phenethylpiperidin-4-yl)acetamide; also known as 2-methyl acetylfentanyl)
Type: Synthetic opioid
AKA: N/A
|
|
II. Natural Derivative
Synthetic substance, no natural derivative
 |
|
III. Chemical Profile (IUPAC name)
|
|
IV. History
The first synthetic narcotic in the world was discovered in 1874 by William Henry Welch, who was working at the West End Chemical Company in New York City. His research team, which included chemist Jacob H. Cohn, a student of Alexander Wilson, and chemist George W. Cooke, was trying to find a replacement for morphine. After testing a number of potential synthetic opioids, Welch decided to investigate the effects of 2-ethyl-2-methyl-1,3-dihydro-2H-benzopyran-4-one (benzodiazepine) on rats. This compound, named 2-ethyl-2-methyl-1,3-dihydro-2H-benzopyran-4-one, was synthesized in 1875 by Alexander Wilson, who had received a patent for the synthesis from Alexander G. Taylor.
In 1876, Welch and Cohn tested the effects of 2-ethyl-2-
|
|
V. Legal Information
Ortho-Methyl Acetylfentanyl is a potent synthetic opioid with high abuse potential. It is regulated under opioid laws to prevent misuse and addiction, with global trends towards tighter controls. [Source: UNODC].
US Federal Schedule - I
Schedule I drugs, substances, or chemicals are defined as drugs with no currently accepted medical use and a high potential for abuse. Some examples of Schedule I drugs are: heroin, lysergic acid diethylamide (LSD), marijuana (cannabis), 3,4-methylenedioxymethamphetamine (ecstasy), methaqualone, and peyote.
Key US Federal Policies:
Controlled Substances Act. Public Law: Public Law 91-513 (text can be found on GovInfo) (https://www.dea.gov/drug-information/csa). Date enacted: October 27, 1970.
|
|
VI. Physical Effects
Ortho-methyl acetylfentanyl is a potent synthetic opioid used for pain relief. It acts as a downer, causing significant sedation and respiratory depression. Short-term use is effective for pain management, but long-term use can lead to addiction and tolerance. Overdose risks include severe respiratory depression and potential death. Safe use requires precise dosing and medical supervision. Recent research examines its potency and safety compared to other opioids.  |
|
VII. Psychological Effects
N/A
 |
|
VIII. Culture
Ortho-methyl acetylfentanyl is a potent synthetic opioid providing pain relief, classifying it as a downer. Short-term use alleviates severe pain, while long-term use can lead to dependence and tolerance. Overdose risks are extremely high, causing respiratory depression and potentially fatal outcomes. Safe dosages are strictly prescribed, often in microgram quantities. Recent research underscores its potency and associated risks of misuse. Physical effects include drowsiness, constricted pupils, and respiratory depression.
 |