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Name: Pentobarbital suppository dosage form
Type: Barbiturate
AKA: WANS
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II. Natural Derivative
Synthetic substance, no natural derivative
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III. Chemical Profile (IUPAC name)
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IV. History
Pentobarbital, a barbiturate, has been used since the 1930s as a sedative and anticonvulsant. Its use in suppository form reflects adaptations for various medical needs. The history of pentobarbital includes its role in sedation and emergency medicine, with evolving use and regulatory measures addressing its potential for abuse and addiction.
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V. Legal Information
Pentobarbital, a barbiturate used for anesthesia and sedation, is classified as a controlled substance in many jurisdictions due to its potential for abuse. In the US, it is regulated under Schedule II. Globally, its status reflects its use in medical settings and efforts to prevent misuse.
US Federal Schedule - III
Schedule III drugs, substances, or chemicals are defined as drugs with a moderate to low potential for physical and psychological dependence. Schedule III drugs abuse potential is less than Schedule I and Schedule II drugs but more than Schedule IV. Some examples of Schedule III drugs are: products containing less than 90 milligrams of codeine per dosage unit (Tylenol with codeine), ketamine, anabolic steroids, testosterone.
Key US Federal Policies:
Controlled Substances Act. Public Law: Public Law 91-513 (text can be found on GovInfo) (https://www.dea.gov/drug-information/csa). Date enacted: October 27, 1970.
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VI. Physical Effects
Pentobarbital, a barbiturate, is used for sedation and seizure control. As a downer, it induces significant drowsiness and relaxation. Short-term effects include sedation and seizure control, while long-term use can lead to dependence and cognitive impairment. Overdose risks involve severe sedation and respiratory issues. Safe dosing involves careful medical supervision. Recent research highlights its use in clinical settings and potential for misuse.  |
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VII. Psychological Effects
Pentobarbital, a barbiturate, affects GABA-A receptors, providing sedation and mood alteration. Immediate effects include euphoria and cognitive impairment, with long-term use carrying risks of dependence and cognitive decline. Research focuses on its efficacy, safety, and psychological impacts.
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VIII. Culture
Pentobarbital, in its suppository dosage form, is used primarily for sedation and euthanasia. It gained cultural significance in the mid-20th century for its medical uses and controversies surrounding euthanasia. Proponents highlight its effectiveness in providing humane end-of-life care, while opponents warn of ethical concerns and potential for misuse. Its use is both medicinal and controversial, reflecting broader debates about euthanasia, palliative care, and medical ethics.
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