|
Name: Phendimetrazine
Type: Stimulant
AKA: Plegine, Prelu-2, Bontril, Melfiat, Statobex
|
|
II. Natural Derivative
Synthetic substance, no natural derivative
 |
|
III. Chemical Profile (IUPAC name)
|
|
IV. History
Phendimetrazine, a stimulant, was developed in the 1950s and used as an appetite suppressant for weight loss. It has since been discontinued in many countries due to its potential for abuse and addiction, but it remains a part of the historical development of weight loss medications.
|
|
V. Legal Information
Phendimetrazine is a stimulant with anorectic effects. It is controlled due to its potential for abuse and impact on mental health, with regulations reflecting concerns about misuse. [Source: UNODC].
US Federal Schedule - III
Schedule III drugs, substances, or chemicals are defined as drugs with a moderate to low potential for physical and psychological dependence. Schedule III drugs abuse potential is less than Schedule I and Schedule II drugs but more than Schedule IV. Some examples of Schedule III drugs are: products containing less than 90 milligrams of codeine per dosage unit (Tylenol with codeine), ketamine, anabolic steroids, testosterone.
Key US Federal Policies:
Controlled Substances Act. Public Law: Public Law 91-513 (text can be found on GovInfo) (https://www.dea.gov/drug-information/csa). Date enacted: October 27, 1970.
|
|
VI. Physical Effects
Phendimetrazine is a stimulant primarily used for weight loss. It acts as an upper, increasing alertness and reducing appetite. Short-term use can effectively manage weight, but long-term use may lead to dependence, cardiovascular issues, and insomnia. Overdose risks include severe cardiovascular effects and central nervous system disturbances. Safe use requires medical supervision to avoid addiction and health complications. Recent research focuses on its effectiveness for weight management and potential for abuse.  |
|
VII. Psychological Effects
Phendimetrazine, a stimulant, affects dopamine and norepinephrine systems, leading to increased alertness and mood enhancement. Immediate effects include improved mood and energy, lasting several hours. Long-term use may result in cognitive impairments and mood disturbances. Research highlights its stimulant effects and associated risks of psychological dependence.
 |
|
VIII. Culture
Phendimetrazine is a stimulant used as an appetite suppressant. Its cultural significance is tied to its role in weight management and obesity treatment. Media coverage often addresses the effectiveness and safety concerns related to appetite suppressants. Phendimetrazine is used medicinally rather than recreationally and is part of broader discussions about obesity, weight loss treatments, and the management of appetite.
 |