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Name: Phenmetrazine
Type: Stimulant
AKA: Preludin
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II. Natural Derivative
Synthetic substance, no natural derivative
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III. Chemical Profile (IUPAC name)
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IV. History
Phenmetrazine is a stimulant drug first synthesized in the 1950s. It was used medically for weight loss under the brand name Preludin. Phenmetrazine gained popularity for its effectiveness in suppressing appetite but was eventually discontinued due to concerns over abuse and addiction. It was replaced by other less addictive stimulants in medical practice.
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V. Legal Information
Phenmetrazine is a stimulant that was previously used as an appetite suppressant but is now a controlled substance in many jurisdictions due to its potential for abuse. In the US, it is classified as a Schedule II controlled substance, reflecting its restricted status. Internationally, phenmetrazine is regulated under various national drug laws with similar controls to prevent misuse. The trend is towards maintaining restrictions on stimulant drugs due to their abuse potential.
US Federal Schedule - II
Schedule II drugs, substances, or chemicals are defined as drugs with a high potential for abuse, with use potentially leading to severe psychological or physical dependence. These drugs are also considered dangerous. Some examples of Schedule II drugs are: combination products with less than 15 milligrams of hydrocodone per dosage unit (Vicodin), cocaine, methamphetamine, methadone, hydromorphone (Dilaudid), meperidine (Demerol), oxycodone (OxyContin), fentanyl, Dexedrine, Adderall, and Ritalin.
Key US Federal Policies:
Controlled Substances Act. Public Law: Public Law 91-513 (text can be found on GovInfo) (https://www.dea.gov/drug-information/csa). Date enacted: October 27, 1970.
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VI. Physical Effects
Phenmetrazine, a stimulant, was used as an appetite suppressant. As an upper, it increases alertness, heart rate, and blood pressure. Short-term effects include reduced appetite and increased energy, while long-term use may lead to cardiovascular issues and dependency. Overdose risks involve severe agitation, cardiovascular complications, and death. Safe dosing was typically low, but its use is now limited due to abuse potential. Recent studies underscore the cardiovascular risks associated with stimulants and caution against misuse.  |
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VII. Psychological Effects
Phenmetrazine, a stimulant, affects neurotransmitter systems to increase alertness and euphoria. Psychological effects include enhanced focus and potential anxiety. Effects last 4-6 hours, with risks of dependence and long-term cognitive impairments. Recent research examines its historical use and current abuse potential.
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VIII. Culture
Phenmetrazine, a stimulant drug, gained popularity in the 1950s and 1960s, primarily for weight loss and treatment of attention disorders. It was notably used in the mod culture of the 1960s, especially in the UK, where it was favored for its energizing effects that complemented the fast-paced lifestyle. The substance also found a place in music and fashion scenes, influencing the cultural landscape of the time. However, its potential for abuse and addiction led to increased regulation and a decline in medical use. Phenmetrazine’s cultural legacy is marked by its dual role as both a medical treatment and a recreational drug.
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