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Name: Propiram
Type: Stimulant
AKA: Algeril
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II. Natural Derivative
Synthetic substance, no natural derivative
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III. Chemical Profile (IUPAC name)
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IV. History
Propiram, a synthetic opioid, was developed in the mid-20th century. It was used for its analgesic effects but has seen limited use compared to other opioids. Its historical importance lies in its contribution to the understanding of opioid receptor interactions and pain management.
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V. Legal Information
Propiram is a synthetic opioid with sedative and analgesic effects. It is classified as a controlled substance due to its potential for abuse. In the U.S., it falls under the Federal Analog Act, which regulates substances similar to known controlled drugs. Internationally, propiram is subject to strict controls to prevent misuse, with regulations aligned with efforts to manage opioid-related issues. [Source: UNODC].
US Federal Schedule - I
Schedule I drugs, substances, or chemicals are defined as drugs with no currently accepted medical use and a high potential for abuse. Some examples of Schedule I drugs are: heroin, lysergic acid diethylamide (LSD), marijuana (cannabis), 3,4-methylenedioxymethamphetamine (ecstasy), methaqualone, and peyote.
Key US Federal Policies:
Controlled Substances Act. Public Law: Public Law 91-513 (text can be found on GovInfo) (https://www.dea.gov/drug-information/csa). Date enacted: October 27, 1970.
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VI. Physical Effects
Propiram is a sedative and hypnotic used for anxiety and insomnia. It causes sedation and muscle relaxation, acting as a downer. Short-term use can be effective for sleep disorders, but long-term use may lead to dependence and cognitive issues. Overdose risks include severe sedation and respiratory depression. Safe use involves careful dosing and medical supervision. Recent research focuses on its efficacy and safety compared to other sedatives.  |
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VII. Psychological Effects
Propiram, an opioid analgesic, affects opioid receptors, causing euphoria and cognitive impairment. Immediate effects include mood enhancement and pain relief, while long-term use can result in dependence and psychological issues such as depression. Effects last several hours, with significant mental health risks with chronic use.
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VIII. Culture
Propiram is an opioid analgesic providing pain relief and sedation, classifying it as a downer. Short-term use alleviates severe pain, while long-term use can lead to dependence and tolerance. Overdose is highly possible, causing respiratory depression and potentially fatal outcomes. Safe dosages are strictly prescribed, typically under 100 mg per day. Recent research stresses the need for cautious prescribing to avoid addiction. Physical effects include drowsiness, constricted pupils, and reduced pain sensation.
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