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Name: Remifentanil
Type: Opioid
AKA: Ultiva
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II. Natural Derivative
Synthetic substance, no natural derivative
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III. Chemical Profile (IUPAC name)
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IV. History
Remifentanil, a potent synthetic opioid, was introduced in the 1990s. It is known for its rapid onset and short duration of action, making it suitable for surgical anesthesia and intensive care. Its development marked a significant advance in anesthetic practices.
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V. Legal Information
Remifentanil, a potent opioid analgesic used in anesthesia, is classified as a controlled substance due to its high potential for abuse. Its use is tightly regulated to manage pain and prevent misuse.
US Federal Schedule - II
Schedule II drugs, substances, or chemicals are defined as drugs with a high potential for abuse, with use potentially leading to severe psychological or physical dependence. These drugs are also considered dangerous. Some examples of Schedule II drugs are: combination products with less than 15 milligrams of hydrocodone per dosage unit (Vicodin), cocaine, methamphetamine, methadone, hydromorphone (Dilaudid), meperidine (Demerol), oxycodone (OxyContin), fentanyl, Dexedrine, Adderall, and Ritalin.
Key US Federal Policies:
Controlled Substances Act. Public Law: Public Law 91-513 (text can be found on GovInfo) (https://www.dea.gov/drug-information/csa). Date enacted: October 27, 1970.
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VI. Physical Effects
Remifentanil is a potent synthetic opioid used for pain management and anesthesia. It acts as a downer, causing sedation and respiratory depression. Short-term use provides effective pain relief, while long-term use may lead to addiction and health issues. Overdose risks include severe respiratory depression and potential death. Safe use involves strict dosing and medical supervision. Recent research focuses on its efficacy in anesthesia and pain management.  |
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VII. Psychological Effects
Remifentanil, an opioid, impacts opioid receptors to provide potent analgesia and mood alteration. Immediate effects include euphoria and significant cognitive impairment, with long-term use carrying risks of dependence and psychological issues. Research focuses on its efficacy and safety.
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VIII. Culture
Remifentanil, a potent opioid analgesic, has no historical or cultural lore but is well-regarded in modern medicine for its use in anesthesia. It is used primarily in surgical settings in Western countries. Its cultural significance lies in its medical applications and the discussions around opioid use in anesthesia and pain management. Proponents emphasize its effectiveness and controllability in surgical settings, while opponents warn of potential misuse and the broader context of opioid dependency and abuse. Its use is strictly medical, with no significant recreational use.
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