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Name: SAM-e (S-adenosylmethionine)
Type: Joint and Mental Health Supplement
AKA: SAMe
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II. Natural Derivative
Synthetic substance, no natural derivative
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III. Chemical Profile (IUPAC name)
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IV. History
S-Adenosylmethionine (SAM-e) is a naturally occurring compound found in all living cells. It is involved in various biochemical processes, including methylation and the synthesis of neurotransmitters. SAM-e has been studied for its potential therapeutic benefits, including the treatment of depression, osteoarthritis, and liver disease. It has been available as a dietary supplement since the 1990s and is valued for its potential health-promoting properties.
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V. Legal Information
S-adenosylmethionine (SAM-e) is a dietary supplement and is not classified as a controlled substance in most countries. It is used for its potential benefits in treating depression and liver disease. Globally, SAM-e is regulated more as a dietary supplement or medication, reflecting its use in therapeutic contexts rather than as a controlled substance.
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VI. Physical Effects
SAM-e, a compound used for mood and joint health, is not classified as a stimulant or depressant. It supports neurotransmitter function and joint health. Short-term effects include improved mood and joint pain relief, while long-term use is generally safe with minimal risks. Overdose risks include gastrointestinal issues. Safe dosing ranges from 200-1600 mg daily. Recent research highlights its effectiveness in treating depression and osteoarthritis with few side effects.  |
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VII. Psychological Effects
SAM-e (S-adenosylmethionine) affects neurotransmitter systems, leading to mood enhancement and cognitive support. Psychological effects include improved mood and potential reduction in depressive symptoms. Effects last several hours, with ongoing research into its role in treating depression and its overall impact on mental health.
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VIII. Culture
SAM-e (S-Adenosylmethionine) is a naturally occurring compound used as a dietary supplement for its potential benefits in treating depression, osteoarthritis, and liver disease. Its cultural significance lies in its representation of the growing interest in natural and alternative health products. SAM-e reflects the broader trend of seeking non-pharmaceutical interventions for health and wellness. The substance highlights the ongoing exploration of natural compounds in modern medicine and the balance between scientific evidence and traditional use. SAM-e's role in the cultural narrative is one of hope and the quest for holistic health solutions.
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