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Name: Tapentadol
Type: Opioid
AKA: N/A
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II. Natural Derivative
Synthetic substance, no natural derivative
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III. Chemical Profile (IUPAC name)
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IV. History
Tapentadol is an analgesic medication approved by the FDA in 2008. It is used to treat moderate to severe pain and works through a dual mechanism of action: as a mu-opioid receptor agonist and a norepinephrine reuptake inhibitor. Tapentadol offers an alternative to traditional opioids with potentially fewer side effects, particularly related to gastrointestinal issues.
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V. Legal Information
Tapentadol is an opioid analgesic classified as a Schedule II controlled substance in the US due to its potential for abuse. Globally, its legal status is similar, with controls focused on managing its use in pain management while preventing misuse. The trend is towards stricter controls on opioids to address addiction and health concerns.
US Federal Schedule - II
Schedule II drugs, substances, or chemicals are defined as drugs with a high potential for abuse, with use potentially leading to severe psychological or physical dependence. These drugs are also considered dangerous. Some examples of Schedule II drugs are: combination products with less than 15 milligrams of hydrocodone per dosage unit (Vicodin), cocaine, methamphetamine, methadone, hydromorphone (Dilaudid), meperidine (Demerol), oxycodone (OxyContin), fentanyl, Dexedrine, Adderall, and Ritalin.
Key US Federal Policies:
Controlled Substances Act. Public Law: Public Law 91-513 (text can be found on GovInfo) (https://www.dea.gov/drug-information/csa). Date enacted: October 27, 1970.
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VI. Physical Effects
Tapentadol, an opioid analgesic, provides effective pain relief. As a downer, it induces sedation and pain relief. Short-term effects include pain management and euphoria, while long-term use may lead to addiction and tolerance. Overdose risks include severe respiratory depression and potential fatality. Safe dosing involves careful monitoring, typically 50-100 mg every 4-6 hours. Recent findings focus on its efficacy for pain relief and the need for caution due to addiction potential.  |
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VII. Psychological Effects
Tapentadol, an opioid analgesic, impacts opioid receptors and norepinephrine systems to relieve pain. Psychological effects include mood elevation and cognitive effects. Long-term use carries risks of dependence and mental health issues. Research examines its efficacy for pain management and potential psychological side effects.
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VIII. Culture
Tapentadol is a synthetic opioid used for pain management with no significant historical or cultural lore. It gained prominence in the 21st century as an alternative to other opioids. Its cultural impact lies in discussions about its effectiveness versus addiction risks. Proponents highlight its balanced analgesic effects, while opponents caution about potential for misuse. Its use is primarily medicinal, reflecting ongoing debates about opioid treatment.
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