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Name: Thiofentanyl
Type: Synthetic opioid
AKA: Chine white, fentanyl
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II. Natural Derivative
Synthetic substance, no natural derivative
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III. Chemical Profile (IUPAC name)
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IV. History
Thiofentanyl is a potent synthetic opioid and analog of fentanyl. It was first developed for its analgesic properties but has been found primarily in the illicit drug market. Thiofentanyl has a high potential for overdose and death, contributing to the challenges in controlling synthetic opioids and addressing the opioid epidemic.
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V. Legal Information
Thiofentanyl, a potent synthetic opioid, is classified as a controlled substance in many countries due to its high potential for abuse. In the US, it is covered under analog laws similar to fentanyl. Globally, it faces strict regulations reflecting concerns about its effects and potential for addiction.
US Federal Schedule - I
Schedule I drugs, substances, or chemicals are defined as drugs with no currently accepted medical use and a high potential for abuse. Some examples of Schedule I drugs are: heroin, lysergic acid diethylamide (LSD), marijuana (cannabis), 3,4-methylenedioxymethamphetamine (ecstasy), methaqualone, and peyote.
Key US Federal Policies:
Controlled Substances Act. Public Law: Public Law 91-513 (text can be found on GovInfo) (https://www.dea.gov/drug-information/csa). Date enacted: October 27, 1970.
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VI. Physical Effects
Thiofentanyl, a potent synthetic opioid, is used for pain relief. As a downer, it induces significant sedation and respiratory depression. Short-term effects include pain relief and euphoria, while long-term use can lead to addiction and tolerance. Overdose risks involve severe respiratory issues and potential fatality. Safe dosing requires careful medical supervision. Recent research focuses on its high potency and the risks of addiction and overdose.  |
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VII. Psychological Effects
Thiofentanyl, a synthetic opioid, binds to opioid receptors, causing strong euphoria and sedation. Psychological effects include mood swings and potential cognitive impairment. Immediate effects last several hours, with long-term use leading to dependence and significant mental health issues. Research examines its potency, abuse potential, and safety compared to other opioids.
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VIII. Culture
Thiofentanyl is a potent synthetic opioid, classifying it as a downer. Short-term use provides significant analgesia, while long-term use can lead to dependence, tolerance, and severe health risks. Overdose risks are extremely high, causing severe respiratory depression and potentially fatal outcomes. Safe dosages are not well-established, with use typically limited to controlled medical environments. Recent research underscores its extreme potency and associated misuse risks. Physical effects include drowsiness, constricted pupils, and severe respiratory depression.
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