Name: Thiofuranyl fentanyl (N-(1-phenethylpiperidin-4-yl)-N-phenylthiophene-2-carboxamide; also known as 2-thiofuranyl fentanyl; thiophene fentanyl)
Type: Synthetic opioid
AKA: N/A
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II. Natural Derivative
Synthetic substance, no natural derivative
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III. Chemical Profile (IUPAC name)
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IV. History
Thiofuranyl fentanyl, a fentanyl analog, emerged in the 2010s as part of a wave of new synthetic opioids. It was developed with modifications to enhance its potency compared to fentanyl. The substance's appearance in the illicit market highlighted the growing issue of synthetic opioids and their role in the opioid crisis. Its high potency and association with overdose deaths have led to increased regulatory scrutiny and efforts to control its distribution.
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V. Legal Information
Thiofuranyl fentanyl is a synthetic opioid with high abuse potential, controlled under the Federal Analog Act in the U.S. Similar substances are regulated globally to manage the opioid crisis and prevent misuse. The trend is towards stricter control of synthetic opioids to address their risks. [Source: UNODC].
US Federal Schedule - I
Schedule I drugs, substances, or chemicals are defined as drugs with no currently accepted medical use and a high potential for abuse. Some examples of Schedule I drugs are: heroin, lysergic acid diethylamide (LSD), marijuana (cannabis), 3,4-methylenedioxymethamphetamine (ecstasy), methaqualone, and peyote.
Key US Federal Policies:
Controlled Substances Act. Public Law: Public Law 91-513 (text can be found on GovInfo) (https://www.dea.gov/drug-information/csa). Date enacted: October 27, 1970.
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VI. Physical Effects
Thiofuranyl Fentanyl is a potent opioid analgesic that causes sedation and pain relief. It leads to constricted pupils, reduced heart rate, and respiratory depression. Short-term effects include effective pain management, while long-term use may result in addiction and respiratory issues. Overdose risks include severe respiratory depression. Safe use requires medical oversight. Recent research highlights its potency and risks associated with opioid use. |
VII. Psychological Effects
Thiofuranyl fentanyl is a potent synthetic opioid inducing euphoria, sedation, and significant analgesia. It acts on mu-opioid receptors, producing immediate mood elevation and cognitive impairment. Long-term use can lead to severe dependence, tolerance, and withdrawal symptoms. Chronic use is associated with mood disorders, cognitive decline, and high overdose risk. Recent findings emphasize the extreme potency and high abuse potential, with severe psychological and physical health impacts.
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VIII. Culture
Thiofuranyl Fentanyl is a synthetic opioid with no historical or cultural lore. It is part of the broader opioid crisis, with significant health risks and societal issues related to its use. Its modern cultural impact is tied to debates over synthetic opioids, their regulation, and their role in the opioid epidemic. Proponents of strict regulation emphasize the dangers of abuse and overdose, while some argue for its medical utility under controlled conditions. Its use is primarily illicit, contributing to public health and law enforcement challenges.
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